OpenFold3 (Claude Skill)
Predicts biomolecular structures with the open-source OpenFold3 model, driven as a Claude skill on local compute.
| Type | Claude Skill |
| Supplier | OpenFold Consortium / AQ Laboratory |
| Availability | GA — Claude Science research skill |
| Pricing | Free / OSS (Apache-2.0 code) |
| Capabilities | Read/Write — writes predicted structures with confidence |
| Verified | works · 2026-07-20 |
| Security | cleared · 2026-07-20 — provenance matches aqlaboratory/openfold, Apache-2.0, no advisories |
How to install
- Claude Science — enable the built-in OpenFold3 research skill (Anthropic-hosted; not published to the public
anthropics/life-sciencesmarketplace). - Run the model yourself — the upstream model is open source:
git clone https://github.com/aqlaboratory/openfoldFollow the repo README for environment setup and model weights.
What it does
Runs OpenFold3, the open reimplementation/extension of the AlphaFold architecture, to predict protein and complex structures. MSA generation runs locally (jackhmmer) or via the ColabFold API; there is no vendor inference API.
Primary use cases: Open-source structure prediction, reproducible folding pipelines, complex modelling
Notes
Claude Science: Featured as a research skill in Anthropic’s Claude Science. Its inclusion there is an independent signal of quality and trustworthiness for life-science work.
Local (your compute); GPU recommended. Fully open training/inference stack.
Sources
- aqlaboratory/openfold
- OpenFold, Ahdritz et al. 2024, Nature Methods
- Anthropic — Claude Science: Connectors and skills
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