Borzoi (Claude Skill)
Predicts cell-type-resolved RNA-seq coverage directly from DNA sequence using Calico’s Borzoi model, driven as a Claude skill.
| Type | Claude Skill |
| Supplier | Calico Life Sciences |
| Availability | GA — Claude Science research skill |
| Pricing | Free / OSS (Apache-2.0; weights on Hugging Face) |
| Capabilities | Read/Write — local inference; writes per-track predicted coverage and variant-effect scores |
| Verified | works · 2026-07-20 |
| Security | cleared · 2026-07-20 — provenance matches Calico, calico/borzoi Apache-2.0, no GitHub advisories |
How to install
- Claude Science — enable the built-in Borzoi research skill (Anthropic-hosted; not published to the public
anthropics/life-sciencesmarketplace). - Run the model yourself — the upstream model is open source:
git clone https://github.com/calico/borzoiFollow the repo README for environment setup and model weights.
What it does
Runs Borzoi to predict RNA-seq (and related assay) coverage tracks from input DNA sequence, and to score the regulatory effect of sequence variants. Local inference only — no external API call.
Primary use cases: Sequence-to-expression prediction, regulatory variant-effect scoring, enhancer/promoter dissection
Notes
Claude Science: Featured as a research skill in Anthropic’s Claude Science. Its inclusion there is an independent signal of quality and trustworthiness for life-science work.
Local (your compute); GPU recommended. Weights distributed via Hugging Face.
Sources
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