Boltz (Claude Code Plugin)

Plugin of agent skills that let Claude run Boltz biomolecular workflows — 3D structure and binding prediction, small-molecule and protein/antibody screening, and de novo binder design — by submitting jobs to the hosted Boltz API.

   
Type Claude Code Plugin (skills) — also a Claude Desktop .mcpb extension
Supplier Boltz (boltz-bio/boltz-api-skills)
Availability GA — listed in anthropics/claude-plugins-official
Pricing Usage-based — Boltz API account required; agent shows a cost estimate before submitting each job (per-job pricing not published)
Capabilities Read/Write — submits compute jobs to the Boltz API and retrieves results
Verified works · 2026-07-20
Security caution · 2026-07-20 — provenance matches boltz-bio (MIT, in official marketplace) but ships a BOLTZ_API_KEY to the hosted paid Boltz API

How to install

  • Claude Code — official marketplace: 
    /plugin install boltz@claude-plugins-official

    (the claude-plugins-official marketplace is available by default; if not found, run /plugin marketplace add anthropics/claude-plugins-official first)

  • Claude Code — upstream marketplace (alternative): 
    claude plugin marketplace add boltz-bio/boltz-api-skills
claude plugin install boltz@boltz-marketplace --scope user
  • Claude Desktop — download the latest .mcpb bundle from the project’s Releases and install via Settings → Extensions → Advanced settings → Install Extension.
  • Install the boltz-api CLI (the skills call it; required on macOS/Linux): 
    curl -fsSL https://install.boltz.bio/boltz-api/install.sh | sh

    Windows PowerShell: irm https://install.boltz.bio/boltz-api/install.ps1 | iex

  • Authenticate the CLI before running any skill (one-time): 
    boltz-api auth login --device-code

    or set export BOLTZ_API_KEY="<your-api-key>" in the shell that launches Claude Code.

What it does

Eight skills wrap the boltz-api CLI (they orchestrate job submission and result retrieval — the computation runs server-side):

  • boltz-cli-setup — CLI installation and authentication.
  • boltz-structure-and-binding — 3D structure prediction with optional binding-affinity scoring.
  • boltz-small-molecule-screen — rank a SMILES library against a target.
  • boltz-small-molecule-design — generate novel small-molecule binders.
  • boltz-small-molecule-adme — estimate ADME properties.
  • boltz-protein-screen — rank proteins, peptides, and antibodies.
  • boltz-protein-design — generate novel peptide/protein binders.
  • boltz-check-status — monitor jobs and recover results.

Primary use cases: target structure prediction, virtual screening, de novo binder/antibody design, early-stage hit-to-lead triage.

Notes

Claude Science: Featured as a research skill in Anthropic’s Claude Science (bundled as Boltz). Its inclusion there is an independent signal of quality and trustworthiness for life-science work.

The Boltz model weights themselves are a separate research artifact (out of scope as a catalog entry); this plugin is in scope because it is an installable Claude component that calls the hosted Boltz API rather than running weights locally — no GPU is required on the user’s machine. Jobs incur API usage cost; the agent surfaces a cost estimate before submitting. Anthropic lists the plugin in the official marketplace but does not control or guarantee third-party plugin behavior. Outputs are for research use; validate predictions experimentally.

Sources

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