cBioPortal MCP Server

Exposes cBioPortal’s cancer genomics studies — mutations, copy-number, and clinical attributes — to Claude via an official MCP server.


Type	MCP server
Supplier	cBioPortal
Availability	GA — official MCP server
Pricing	Free / OSS (data ODbL; some studies access-restricted)
Capabilities	Read-only
Verified	works · 2026-07-20
Security	caution · 2026-07-20 — official cBioPortal repo, maintained, read-only, but no SPDX LICENSE detected

How to install

Claude Code / Desktop — MCP server (cBioPortal/cbioportal-mcp, OSS):
```
git clone https://github.com/cBioPortal/cbioportal-mcp
cd cbioportal-mcp
uv run cbioportal-mcp
```
See https://docs.cbioportal.org/ai-integrations/mcp/ for setup.
Claude Science — also available as the Cancer Models featured connector (Anthropic-hosted).
Public API — cbioportal.org/api.

What it does

Search cancer studies, retrieve mutation / CNA / clinical profiles for genes and samples, and pull study metadata across the cBioPortal public instance and compatible deployments.

Primary use cases: Cancer genomics lookup, cohort/mutation queries, biomarker exploration

Notes

Claude Science: Offered inside Anthropic’s Claude Science via the Cancer Models featured connector. Its inclusion there is an independent signal of quality and trustworthiness for life-science research.

Official server maintained by the cBioPortal project. Some studies carry access restrictions even though the portal is open (ODbL).

Sources

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