ESM (Claude Skill)

Comprehensive toolkit for EvolutionaryScale protein language models including ESM3 (generative multimodal design across sequence, structure, and function) and ESM C (efficient embeddings).

   
Type Claude Skill
Supplier K-Dense Inc. (community OSS)
Availability GA — part of the actively maintained K-Dense scientific-agent-skills collection
Pricing Free / OSS (MIT)
Capabilities Read/Write — Claude runs the skill’s Python locally (Bash), not as an MCP tool

How to install

  • Also packaged in the SciAgent-Skills collection (jaechang-hits (community OSS, CC BY 4.0)): clone jaechang-hits/SciAgent-Skills and run /plugin install sciagent-skills in Claude Code (or copy skills/proteomics-protein-engineering/esm-protein-language-model into ~/.claude/skills/).
  • Claude Code / Claude.ai — Skills CLI (recommended): 
    npx skills add K-Dense-AI/scientific-agent-skills

    Installs the K-Dense collection; enable the esm skill when prompted. Works across Claude Code, Cursor, and Codex via the Agent Skills spec (requires Node ≥ 18).

  • Claude Code / Claude Desktop — manual clone: 
    git clone https://github.com/K-Dense-AI/scientific-agent-skills
cp -r scientific-agent-skills/skills/esm ~/.claude/skills/

    Project-scoped alternative: copy into .claude/skills/ instead of ~/.claude/skills/. The skill declares its own Python dependencies in its SKILL.md; install them (the K-Dense skills generally use uv / pip) when prompted on first use.

What it does

Comprehensive toolkit for EvolutionaryScale protein language models including ESM3 (generative multimodal design across sequence, structure, and function) and ESM C (efficient embeddings). Use for protein sequence/structure/function tasks, inverse folding, embeddings, variant design, and ESMFold2 structure prediction via Biohub. Supports local open weights (Python 3.12, esm on PyPI) and cloud Forge/Biohub APIs with ESM_API_KEY authentication.

Primary use cases: protein sequence/structure/function tasks, inverse folding, embeddings, variant design, and ESMFold2 structure prediction via Biohub.

Notes

Distributed as a SKILL.md (plus code examples) in the K-Dense collection — Claude executes it locally via Bash/Python rather than as an MCP server. Upstream license: MIT. The skill name to enable after install is esm.

Sources

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