CovaSyn Chemistry MCP

Hosted MCP server that gives Claude a broad, deterministic drug-discovery toolbox — cheminformatics, ADMET, retrosynthesis, docking, and regulatory toxicology — over a single API.

   
Type MCP server (hosted, streamable-HTTP)
Supplier CovaSyn
Availability GA — registry version 1.27.2, last updated 2026-06-02
Pricing Freemium — free tier 100 credits/week; Pro €250/mo; Unlimited €750/mo; Enterprise (contact, GxP validation)
Capabilities Read/Write — molecular computation and analysis; no persistent state

How to install

An API key is required. Create a free account at covasyn.com to obtain COVASYN_API_KEY.

  • Claude Code — direct MCP add (remote streamable-HTTP): 
    claude mcp add --transport http covasyn https://mcp.covasyn.com/mcp --header "Authorization: Bearer YOUR_COVASYN_API_KEY"

    (replace YOUR_COVASYN_API_KEY with the key from your CovaSyn account. Unverified — the upstream repo documents the @covasyn/mcp-client stdio proxy below rather than a header-auth HTTP form; if the remote endpoint rejects the header, use the Desktop/stdio proxy entry instead.)

  • Claude Desktop — stdio via the published npm proxy client, in claude_desktop_config.json: 
    {
  "mcpServers": {
    "covasyn": {
      "command": "npx",
      "args": ["-y", "@covasyn/mcp-client"],
      "env": {
        "COVASYN_API_KEY": "your_api_key_here",
        "COVASYN_API_BASE": "https://api.covasyn.com"
      }
    }
  }
}
  • Claude Code — equivalent stdio proxy (mirror of the Desktop entry): 
    claude mcp add --transport stdio covasyn --env COVASYN_API_KEY=your_api_key_here --env COVASYN_API_BASE=https://api.covasyn.com -- npx -y @covasyn/mcp-client

The hosted endpoint is a long-lived remote service maintained by CovaSyn — there is nothing to keep running locally; the npx proxy launches on demand via stdio when Claude starts.

What it does

Exposes 130+ deterministic tools grouped into suites, including:

  • covabasic — core cheminformatics: canonicalization, fingerprints, druglikeness
  • covachem — ADME, pKa, chemical profiling
  • covatox — toxicology with ICH M7 assessment and CYP450 analysis
  • covams / covanmr — mass-spectrometry and 1D/2D/batch NMR analysis
  • covafold — protein and RNA folding
  • covabio — antibody, peptide, ADC, and biologics tools
  • covaplatform — stability, design of experiments, docking, chromatography, retrosynthesis

Primary use cases: ADMET profiling, molecular docking, retrosynthetic analysis, ICH M7 regulatory toxicology, lipid-nanoparticle and biologics design.

Notes

Streamable-HTTP transport; EU-hosted (Hetzner Leipzig) by default with US hosting available. API key required; usage is metered in credits against the chosen plan. The example client snippets in the repo are MIT-licensed, but the CovaSyn service itself is commercial. Covers two open catalog gaps (a Claude-installable retrosynthesis and an ADMET tool) in a single hosted server.

Sources

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